1: Nippon Rinsho 1995 Mar;53(3):574-9

[Phenotypic analysis of myeloma cells].

[Article in Japanese]

Mihara K, Harada H, Kawano MM

Recent 2-color phenotypic analysis using anti-CD38 antibody reveals that plasma
cells alone locate at CD38strong positive (CD38++) fraction and expression of
adhesion molecules such as VLA-5 and MPC-1 can define VLA-5-MPC-1- immature,
VLA-5-MPC-1+ intermediate and VLA-5+ MPC-1+ mature plasma (myeloma) cells.
Furthermore, phenotypic analysis of plasma cells with anti-CD19 and -CD56
antibodies can distinguish normal (polyclonal) plasma cells from malignant
(monoclonal) plasma cells; normal plasma cells from various tissues are all
CD19+ CD56-, while malignant plasma cells are mostly CD19- CD56+. Therefore,
this 2-color phenotypic analysis is very useful for differential diagnosis of
bone marrow plasmacytosis, that is, myeloma, benign monoclonal gammopathy or
polyclonal gammopathy, and furthermore contributes to understanding of
differentiated stages of myeloma cells (immature, intermediate or mature myeloma
cells).

Publication Types:
Review
Review literature

PMID: 7699888, UI: 95214262